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[(en)20.1(ce)20.4(ph)18.6(a)13.3(l)0(i)20.6(t)0(i)18.9(s)]TJ /F11 1 Tf 4.5951 0 TD (?Tj /F9 1 Tf 0.734 0 TD [(fo)21.2(r)-346.2(t)0(h)21.4(e)]TJ /F10 1 Tf 3.0495 0 TD ()Tj /F9 1 Tf 0.5192 0 TD -0.0119 Tc [(rs)-11.9(t)-348.5(t)-11.9(i)13(m)-11.9(e)-347.4(\()]TJ 0 0 0 0.7 k 3.7895 0 TD 0 Tc (2)Tj 0 0 0 1 k 0.4655 0 TD [(\).)-334.2(In)-331.5(20)21.1(07)21.1(,)-343(D)0(a)20.2(l)0(m)17.7(a)13.3(u)-345.3(e)0(t)-332.3(a)13.3(l.)]TJ /F10 1 Tf 10.2882 0 TD ()Tj /F9 1 Tf 0.5252 0 TD -0.0119 Tc [(rst)-11.9(l)9(y)]TJ -23.9661 -1.2114 TD 0.0432 Tc [(ident)5(i)]TJ /F10 1 Tf 2.5542 0 TD 0 Tc ()Tj /F9 1 Tf 0.5729 0 TD 0.0425 Tc [(ed)-553.5(t)4.3(h)0.6(e)-556(s)0.7(o-called)]TJ /F11 1 Tf 7.9429 0 TD 0 Tc (?Tj /F9 1 Tf 0.4356 0 TD 0.0436 Tc [(an)5.7(ti)-549.8(NMDAR)-553.8(e)0.1(n)5.7(cephali)5.2(tis)]TJ /F11 1 Tf 11.9055 0 TD 0 Tc (?Tj /F9 1 Tf 0.4356 0 TD 0.5936 Tc [(,b)550.5(y)]TJ -23.8468 -1.2114 TD 0 Tc [(co)20.8(n)]TJ /F10 1 Tf 1.4263 0 TD ()Tj /F9 1 Tf 0.5192 0 TD 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(de)Tj /F10 1 Tf 0.9906 0 TD 0 Tc ()Tj /F9 1 Tf 0.555 0 TD 0.0264 Tc [(ned)-539.7(i)0(n)-536.6(2)4.1(016)-538.9(b)1.2(y)-536.1(G)0.4(raus)-534.6(et)-536.9(al.)-531.4(\()]TJ 0 0 0 0.7 k 13.839 0 TD 0 Tc (4)Tj 0 0 0 1 k 0.5072 0 TD 0.0266 Tc [(\))-537.5(W)4(ith)-534.5(t)0.4(he)-536.1(deepening)]TJ -15.8919 -1.2055 TD 0 Tc [(un)-13.2(der)-12.9(st)-14.3(and)-11.8(i)-8.5(n)-8(g)-520.7(o)0(f)-521.9(a)0(u)-9.8(t)-8.3(oi)-9.8(mm)-11.1(un)-13.2(e)-520.9(e)0(n)-9.8(c)0(e)-9.4(p)0(h)-11.2(a)0(l)-11.2(i)0(t)-10.9(i)0(s)-8.6(,)-522(mo)-12.8(re)-521(a)-10.6(n)0(d)-526.4(m)0(o)-6.9(r)0(e)]TJ 0 -1.2114 TD 0.0191 Tc [(auto)5.9(an)5.1(ti)4.6(bodi)4.6(e)-0.5(s)-524(a)2.6(ssoci)4.6(ated)-523.1(wi)4.6(th)-524.1(AE)-522.9(we)5.4(re)-531.7(di)4.6(scov)5.7(ered,)-526.8(w)3.9(hi)4.6(ch)]TJ T* 0 Tc 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[(\),)-262.5(gl)21.7(u)12.8(t)0(a)16.9(m)12.3(ic)-260.9(ac)17.5(id)-258.4(de)17(ca)17.5(r)11.9(b)0(o)21.3(x)0(y)18.9(l)0(a)24.6(s)0(e)-264.3(6)0(5)21.1(-)0(k)19.5(D)]TJ -11.1237 -1.2114 TD [(is)21.3(of)21.2(or)16.6(m)-256.2(\()0(G)18.6(A)0(D)-249(6)0(5)15.1(\))-259.7(\()]TJ 0 0 0 0.7 k 7.8654 0 TD (7)Tj 0 0 0 1 k 0.4655 0 TD [(\),)-250.6(an)17.2(d)-261.8(c)0(o)20.8(l)0(l)22.6(a)0(p)20.1(s)11.9(in)-255.3(r)11.9(e)0(s)22.1(p)0(o)17.4(n)0(s)21.8(e)-264.3(m)12.3(e)0(d)17(i)0(a)22.7(t)0(o)20.2(r)-262.6(p)12.7(r)0(o)16.6(t)15.6(ei)19.6(n)-264.6(5)]TJ -8.3308 -1.2055 TD [(\(C)20.3(V2)18.3(\))-456.7(\()]TJ 0 0 0 0.7 k 3.2703 0 TD (8)Tj 0 0 0 1 k 0.4655 0 TD [(\);)-447.5(ex)18.7(tr)21.5(ac)17.5(el)21.5(lu)18.1(la)24.6(r)-459.5(s)11.9(yn)20.3(ap)14.1(t)15.6(i)0(c)-451.9(p)12.7(r)11.9(o)0(t)20.2(e)0(i)19.6(n)0(s)15.8(,)-456.3(s)11.9(u)0(c)17(h)-453.7(as)-452.2(le)21.5(u)12.7(c)0(i)19.6(n)0(e)20.1(-)0(r)19.8(i)0(c)19.6(h)]TJ -3.7358 -1.2114 TD [(gl)21.7(io)20(m)12.3(a)0(-)15.2(i)15.3(na)17.2(ct)19.8(iv)19.8(a)13.3(t)0(e)19.8(d)-291.6(1)-296.8(\()14.8(LG)15.6(I1)24.3(\))-295.5(\()]TJ 0 0 0 0.7 k 11.625 0 TD (7)Tj 0 0 0 1 k 0.4655 0 TD (,)Tj 0 0 0 0.7 k 0.5132 0 TD (9)Tj 0 0 0 1 k 0.4655 0 TD [(\);)-286.4(a)13.3(n)0(d)-281.7(c)0(e)20.4(l)0(l)-281.8(s)0(u)18.7(r)11.9(fa)17.8(ce)-284(a)13.3(n)0(t)19.5(i)0(g)19.8(e)0(n)20.1(s)-292.4(s)11.9(u)0(c)17(h)]TJ -13.0692 -1.2114 TD [(as)-494(an)11.2(ti)13(-)]TJ /F12 1 Tf 3.1569 0 TD (a)Tj /F9 1 Tf 0.6206 0 TD [(-am)15.6(in)13.3(o-)12.6(3-h)15.3(yd)11.2(rox)19.1(y-)12.3(5-m)15.8(eth)19.7(yl-)17.7(4-i)12.8(sox)19.1(az)11.6(ole)14.2(pr)12.7(op)11.5(io)14(nic)-489.8(ac)11.6(id)]TJ -3.7775 -1.2114 TD [(re)-13.7(c)-7.7(e)-7.7(p)0(t)-13.5(o)-7.3(r)-525.2(\()-9.1(AM)-9.4(P)-10.9(A)0(R)-11.9(\))-528.3(\()]TJ 0 0 0 0.7 k 8.9097 0 TD 0.0103 Tc (10)Tj 0 0 0 1 k 0.9727 0 TD 0.0086 Tc [(\),)-513.4(ant)8.6(i)-2.3(-r)8.6(e)-5.1(cep)8.6(t)-4.9(o)1.4(r)-510.6(a)-2(nt)8.6(ibod)8.6(y)-523.2(e)0.9(ncep)8.6(hali)8.6(tis)]TJ -9.8824 -1.2114 TD 0.0286 Tc [(\(anti)-3.8(-)0.7(NMDAR\))-535.5(\()]TJ 0 0 0 0.7 k 7.4894 0 TD 0 Tc (3)Tj 0 0 0 1 k 0.5073 0 TD 0.0271 Tc [(\),)-542.6(and)]TJ /F12 1 Tf 3.2822 0 TD 0 Tc (g)Tj /F9 1 Tf 0.4297 0 TD 0.0275 Tc [(-ami)-4.9(no)-3.6(buty)-3.8(ric)-541.2(a)-1(c)-4.1(i)1.1(d)-538.6(e)-4.1(nc)-4.1(ephaliti)-4.9(s)]TJ -11.7085 -1.2114 TD 0 Tc [(\(G)18.6(A)12.7(B)0(A)16.8(R)0(\))-475.2(\()]TJ 0 0 0 0.7 k 4.7264 0 TD (11)Tj 0 0 0 1 k 0.9369 0 TD [(\))-492.5(h)11.8(as)-482(be)20.9(en)-481.2(r)11.9(e)0(p)17(o)0(r)22.6(t)0(e)19.8(d)12.8(.)-492.1(A)0(m)19(o)0(n)20.5(g)-490.9(th)21.4(em)22.5(,)-492.2(t)0(h)21.4(e)-491.1(vo)21.1(lt)20.9(ag)17.7(e-)]TJ -5.6633 -1.2114 TD [(ga)17.8(t)15.6(e)0(d)-460.4(p)12.7(ot)20.2(a)13.3(s)0(s)17.8(i)0(u)16.1(m)-459.1(ch)16(a)13.3(n)0(n)19.8(e)0(l)-455.9(\()0(V)19.5(G)0(K)19.3(C)0(\))-457.1(i)15.3(s)-465.5(a)-464.1(we)18.8(ll)22.6(-k)19.5(no)20.5(wn)-458.9(m)12.3(e)0(m)22.5(b)0(r)16.6(a)13.3(ne)]TJ 0 -1.2055 TD [(pr)18.7(ot)20.2(ei)19.6(n)-282.5(c)0(o)20.8(m)12.3(pl)18.1(ex)-273.7(th)21.4(a)13.3(t)-282.8(wa)15.9(s)-280.5(c)0(o)20.9(m)12.3(mo)17(nl)21.2(y)-282(b)0(o)21.3(u)0(n)16.7(d)-279.7(by)-271.3(an)17.2(ti)18.9(bo)21.3(d)12.8(i)0(e)19.6(s)-286.5(i)15.3(n)-282.5(AE)19.7(.)]TJ 0 -1.2114 TD [(A)12.7(s)-310.3(pa)20.1(r)11.9(t)0(s)-300.8(o)0(f)-295.1(V)0(G)20.5(K)0(C)15.1(,)-307.2(le)21.5(u)12.7(c)0(i)19.6(n)0(e)20.1(-)0(r)19.8(i)0(c)19.6(h)-310.4(gl)21.7(io)20(m)12.3(a)0(-)21.2(i)0(n)19.2(a)0(c)17.5(t)0(i)24.9(v)0(a)17.8(t)0(e)19.8(d)-309.5(1)-308.7(\()14.8(LG)15.6(I1)24.3(\))-307.5(a)0(n)17.2(d)]TJ T* [(co)20.8(nt)19.5(a)13.3(c)0(t)19.8(i)0(n)19.2(-)0(a)21.2(s)0(s)17.8(o)0(c)20.9(i)0(a)16.7(t)15.6(ed)-233.7(pr)18.7(ot)20.2(ei)19.6(n-)17.7(2)-243.1(\()14.8(CA)18.2(SP)21.5(R2)18.8(\))-241.8(c)0(o)20.9(u)0(l)18.1(d)-243.9(be)-229.8(de)17(te)19.8(ct)19.8(ed)-233.7(in)-231.4(th)21.4(e)]TJ T* [(im)21.7(mu)19.1(no)20.5(pr)18.7(ec)20.4(ip)16.1(i)15.3(t)0(a)16.9(t)0(i)18.9(o)0(n)-277.9(w)14.6(it)18.9(h)-292.5(p)12.7(at)16.9(ie)19.6(nt)25.4(s)]TJ /F11 1 Tf 13.7435 0 TD (?Tj /F9 1 Tf 0.5072 0 TD -0.0157 Tc [(au)-15.7(to)-15.7(a)8.2(n)-15.7(t)3.8(i)-15.7(b)4.3(o)-15.7(di)-15.7(e)3.9(s)-302.2(\()]TJ 0 0 0 0.7 k 6.3496 0 TD 0 Tc (12)Tj 0 0 0 1 k 0.9369 0 TD (,)Tj 0 0 0 0.7 k 0.5073 0 TD (13)Tj 0 0 0 1 k 0.9369 0 TD (\).)Tj -21.7163 -1.2114 TD [(CASPR2)-329.4(is)-330.8(a)-332.8(cellular)-331.5(adhesion)-333.9(molecule)-334.8(\(CAM\))-332.4(and)-334.1(part)-328.4(of)]TJ -1.2651 -1.2114 TD [(the)-368.2(neurexin)-376.9(family)-368.4(\()]TJ 0 0 0 0.7 k 8.7426 0 TD (13)Tj 0 0 0 1 k 0.9548 0 TD [(\).)-370(It)-373.5(regulates)-369.9(the)-368.2(formation)-373.3(of)-372.7(distinct)]TJ -9.6974 -1.2055 TD [(a)-10.6(x)0(o)-10.7(n)-8(a)-10.6(l)-513.9(do)-12.4(m)-11.5(a)0(i)-13.2(n)-8(s)-513.2(a)-10.6(ro)-13.2(u)-11.1(n)-8(d)-512.4(t)-8.3(he)-521(n)-8(o)-7.2(d)-11.1(e)-7.7(s)-513.2(o)-7.3(f)-514.6(R)-12.6(an)-12.6(v)-7.5(i)-8.5(e)-7.7(r)0(,)-522(s)-12(e)-7.7(r)0(v)-13.5(i)-8.5(n)-8(g)-514.7(as)-523.8(a)]TJ 0 -1.2114 TD 0.0645 Tc [(membr)4.8(a)0.2(ne)-563.8(s)4.8(c)-2.9(af)64.5(fold)-567.3(that)-564.5(clus)4.8(ters)-562.1(Kv1)-560.5(c)-2.9(h)4.7(a)0.2(nnels)-568.1(a)0.2(t)-558.5(t)-3.5(h)4.7(e)]TJ T* 0.0283 Tc [(juxtap)5.2(aranod)5.2(al)-527.3(region)-528.7(\()]TJ 0 0 0 0.7 k 10.5031 0 TD (14)Tj 0 0 0 1 k 1.0145 0 TD 0.0273 Tc [(\).)-530.5(C)3(A)-1.8(SPR2)-532.1(is)-527.7(a)-526.3(t)1.1(ransmembrane)]TJ -11.5176 -1.2114 TD 0 Tc [(pro)-12.4(tei)-12.6(n)-503.3(wit)-8.2(h)-507.4(i)-8.5(ts)-509.6(C-t)-6.9(e)-7.7(rmi)-8.2(nal)-514.6(por)-12.4(tio)-12.2(n)-503.3(i)0(n)-10.6(ter)-10.1(act)-8.7(in)-10.6(g)-502.8(w)0(i)-11.9(t)0(h)-509.7(prot)-14.8(ein)]TJ T* (4.1B)Tj /F11 1 Tf 1.7605 0 TD (?Tj /F9 1 Tf 0.919 0 TD [(an)-305(ankyrin)-305.6(protein)-313.6(that)-301.9(may)-310.1(link)-304(the)-308.6(juxtaparanodal)-312.9(and)]TJ -2.6795 -1.2114 TD [(paranodal)-350.4(adhesion)-351.8(complexes)-355.5(to)-349.8(the)-350.3(axonal)-350.8(cytoskeleton.)-348.1(It)-349.7(is)]TJ 0 -1.2055 TD [(located)-262.2(in)-261.2(neurons)-269(in)-261.2(the)-260.8(limbic)-265(system,)-264.7(basal)-261.8(ganglia,)-265(and)-262.5(other)]TJ 0 -1.2114 TD [(motor)-285(areas)-291.5(and)-286.3(sensation)-285.3(pathways)-290.3(and)-286.3(is)-283.1(rich)-290.9(in)-285.1(the)-284.7(temporal)]TJ T* [(lobe,)-300.2(especially)-306.8(in)-303(the)-296.6(GAD65)-301.7(positive)-303.7(inhibitory)-302.8(neurons)-304.8(\()]TJ 0 0 0 0.7 k 23.8706 0 TD (15)Tj 0 0 0 1 k 0.9548 0 TD (\).)Tj -23.5603 -1.2114 TD -0.0215 Tc [(Anti-CASPR2)-312.3(a)-2.2(ntibodies)-313.9(h)2.3(ave)-309.7(b)-4.9(een)-310(reported)-313.1(i)5.8(n)-316(various)-308(c)0.6(li)5.8(n)-5.6(i)5.8(c)-5.3(a)3.7(l)]TJ 9.5 0 0 9.5 45.3543 120.1323 Tm [(conditions)-314(\()]TJ 0 0 0 0.7 k 4.6249 0 TD 0 Tc (4)Tj 0 0 0 1 k 0.4535 0 TD 0.2955 Tc (\)\()Tj /F13 1 Tf 0 0 0 rg 0.9608 0 TD -0.0228 Tc [(Supp)-7(lement)-6.1(ary)-316.7(F)-1.9(igure)-311.9(1)]TJ /F9 1 Tf 0 0 0 1 k 9.6915 0 TD 0.2882 Tc [(\))308.9(.)-7(O)311.1(n)-0.3(o)304.8(n)310(eh)306(a)313.4(n)310(d)306.9(,)-1.1(t)309.7(h)306(eg)310.6(r)306.1(e)310.3(a)313.4(t)]TJ -15.7307 -1.2114 TD -0.0155 Tc [(variation)-506.9(i)-0.2(s)-504.9(c)0.7(onsidered)-510(t)0.1(o)-506.1(b)1.1(e)-506.6(p)3.2(artl)-15.5(y)-495.1(a)3.8(ssociated)-510(w)5.1(ith)-510.9(s)2.4(igni)]TJ /F10 1 Tf 23.4947 0 TD 0 Tc ()Tj /F9 1 Tf 0.5192 0 TD -0.0168 Tc (cant)Tj -24.0138 -1.2114 TD 0 Tc [(va)17.8(ri)15.3(a)13.3(t)0(i)18.9(o)0(n)-498.7(i)0(n)-494(e)0(p)17(i)0(t)18.9(o)0(p)17.4(e)0(s)-497.1(\()]TJ 0 0 0 0.7 k 9.3633 0 TD (1)Tj 0 0 0 1 k 0.4655 0 TD (,)Tj 0 0 0 0.7 k 0.7281 0 TD (5)Tj 0 0 0 1 k 0.4655 0 TD (,)Tj 0 0 0 0.7 k 0.7221 0 TD (6)Tj 0 0 0 1 k 0.4714 0 TD [(\).)-495.3(On)-498.4(th)21.4(e)-503(o)0(t)20.2(h)0(e)16(r)-507.3(h)11.8(a)0(n)17.2(d)0(,)-497.3(t)0(h)21.4(e)-503(wi)18(de)]TJ -12.2158 -1.2055 TD -0.0172 Tc [(expres)6.6(sio)5.4(n)-502.6(of)-502(C)6.2(A)1.4(SPR2)-499(i)4.1(n)-502.6(bo)5.4(th)-500.7(ce)4.9(nt)4.3(ral)-501.2(a)2.1(nd)-499.8(peri)4.1(pheral)-501.2(n)4.6(e)-1(rv)5.2(ous)]TJ 0 -1.2114 TD -0.0216 Tc [(system)-337.5(allows)-337.9(various)-337.9(f)0.9(orms)-337.9(of)-339.3(involvement)-340.2(\()]TJ 0 0 0 0.7 k 17.7239 0 TD -0.0255 Tc (16)Tj 0 0 0 1 k 0.9131 0 TD -0.0203 Tc [(\).)-333.4(Besid)4.4(e)1.8(s,)-333.4(ther)3.5(e)-338.3(i)1(s)]TJ 8.8142 58.0474 TD -0.0217 Tc [(an)-322.1(overlap)-325.2(b)0.9(etwe)-5.5(en)-322.1(peptides)-326.1(of)-327.5(LGI1)-324.5(and)-325.2(C)1.7(ASPR2.)-322.9(Thus,)-322.9(p)-3(ositive)]TJ 0 -1.2055 TD -0.0222 Tc [(immunob)-5.6(i)5.1(n)-6.3(d)2.5(ing)-399.7(o)-5.6(f)-399.6(t)-0.7(he)-405.9(autoantibody)-399.7(t)-0.7(o)-405.4(both)-398.3(L)-4.4(GI1)-402.5(a)3(nd)-403.3(C)-4.7(A)2.4(SPR)-5(2)]TJ 0 -1.2114 TD -0.0218 Tc [(might)-274.8(b)0.8(e)-274.2(observed.)-275.2(This)-278.4(could)-277.6(e)0.3(xplain)-274.5(the)-274.2(e)0.3(xpande)-5.6(d)-271.6(p)-3.1(henotypes)-272.5(i)-0.5(n)]TJ T* -0.0215 Tc [(additi)5.8(o)-4.9(n)-333.9(t)6(o)-333.1(c)-5.3(l)1.7(assical)-332.5(f)1(eatures)-331.8(o)1.1(f)-333.2(C)-4(ASPR2)-330.2(a)-2.2(utoimmune)-333.6(e)0.6(ncephalitis)]TJ T* -0.0211 Tc [(as)-200.2(clinical)-200.8(presentations)-206.1(a)4.1(re)-201.9(consis)]TJ 12.7409 0 TD -0.0217 Tc [(tent)-203.1(with)-200.9(the)-208.4(a)3.5(ntigenic)-202.5(localization)]TJ -12.7409 -1.2114 TD 0 Tc [(and)-513.1(funct)11.1(ion)-507.2(of)-515.9(LGI1)-509.1(and)-513.1(CASPR)15.1(2)-517.6(\()]TJ 0 0 0 0.7 k 16.0649 0 TD (7)Tj 0 0 0 1 k 0.4774 0 TD [(\).)-513.2(Howev)12.2(er,)-511.8(the)-511.5(HLA)]TJ -16.5423 -1.2114 TD -0.0215 Tc [(DRB1*11:01)-300.4(i)5.8(m)-3.2(plicated)-301.2(in)-298.1(CASPR2)-300.4(is)-296(not)-304.3(a)3.7(ssociated)-301.2(w)5(ith)-302.1(L)2.2(GI1.)]TJ 1.2651 -1.2055 TD 0.0331 Tc [(The)-529.6(p)-1.9(athog)-4.2(e)1.5(ne)-4.4(sis)-533.9(i)-5.3(n)-529.9(a)-1.3(nt)-5.1(i-CASPR2)-532.2(antib)-4(o)2(dy-asso)-4(c)1.5(iate)-4.4(d)]TJ -1.2651 -1.2114 TD 0 Tc [(di)-13.7(se)-13.7(as)-16.6(e)-509(i)-8.5(s)-513.2(b)-7.3(e)-7.7(l)-6.6(ie)-10.3(v)-7.5(e)-7.7(d)-512.4(t)-8.3(o)-514.5(b)0(e)-516.2(d)-11.1(ue)-520.1(to)-516.9(t)-8.3(h)0(e)-515.1(b)-7.3(l)-6.6(o)-7.3(c)-7.7(k)0(i)-14.9(n)-8(g)-508.8(a)-10.6(c)-7.7(t)0(i)-10.9(o)-7.2(n)-515.3(o)0(f)-515.9(t)-8.3(he)]TJ T* 0.0726 Tc [(in)4.9(teract)4.6(io)5.7(n)-574(b)-0.3(e)5.2(t)-1.4(ween)-568(CASPR2)-570.3(and)-571.1(C)0.5(on)4.9(tact)4.6(in-2)-570.3(\()]TJ 0 0 0 0.7 k 23.3574 0 TD 0 Tc (6)Tj 0 0 0 1 k 0.549 0 TD (,)Tj 0 0 0 0.7 k 0.8593 0 TD (8)Tj 0 0 0 1 k 0.549 0 TD (\))Tj -25.3148 -1.2114 TD (\()Tj /F13 1 Tf 0 0 0 rg 0.3461 0 TD [(Supplementary)-482.3(Figure)-486.7(1)]TJ /F9 1 Tf 0 0 0 1 k 10.4732 0 TD [(\))-480.5(thus)-479.1(disrupting)-492.1(the)-481.6(expression)-483.6(of)]TJ -10.8194 -1.2114 TD 0.0119 Tc [(Kv1)-517.6(c)4.2(hannels.)-516.1(In)-509.3(some)-515(cases,)-510.1(d)-5.2(e)-1.8(cr)-6(eased)-512.4(e)-1.8(xpr)-6(e)4.2(ss)-6(ion)-515.3(o)4.6(f)-514.7(K)-2.4(v1)]TJ T* 0 Tc [(channels)-454.6(was)-455.5(found)-450.7(in)-452.2(areas)-458.6(such)-448.7(as)-458.2(dorsal)-453.4(root)-452.5(ganglia)-453.2(\()]TJ 0 0 0 0.7 k 24.6166 0 TD (9)Tj 0 0 0 1 k 0.4834 0 TD (\),)Tj -25.1 -1.2055 TD [(and)-226.7(in)-225.4(some)-229.4(others,)-229.2(an)-227.5(increased)-228.5(expression)-232.9(of)-223.5(Kv1)-229.1(channels)-227.8(was)]TJ 0 -1.2114 TD 0.0316 Tc [(induced,)-532.2(e)0(specially)-530.9(in)-531.4(the)-531.1(i)-0.8(nhibit)5.4(ory)-530.9(i)5.2(nterneurons)-529.4(i)-0.8(n)-531.4(t)-0.6(he)]TJ T* 0.01 Tc [(h)10(i)-4.6(ppocam)10(p)-6.7(us)-503.2(\()]TJ 0 0 0 0.7 k 6.3556 0 TD 0 Tc (6)Tj /F11 1 Tf 0 0 0 1 k 0.4893 0 TD (?Tj /F9 1 Tf 0 0 0 0.7 k 0.5192 0 TD (8)Tj 0 0 0 1 k 0.4893 0 TD [(\).)-525.1(T)-6.6(h)0(i)-14.6(s)-519.2(m)-11.5(i)-8.5(g)-7.5(h)0(t)-521.7(c)-13.7(au)-15.7(s)-12(e)-514.9(hy)-13.6(p)-11.1(e)-7.7(r)-12(e)-7.7(x)-9.4(c)-7.7(i)-8.5(t)-8.3(a)-10.6(b)-7.2(i)-8.5(l)-6.6(i)-8.6(t)-8.3(y)-520.7(a)0(n)-18.6(d)]TJ -7.8534 -1.2114 TD [(netw)-9.5(or)-7.3(k)-501.6(d)0(i)-7.7(s)0(t)-8.4(urba)-11.1(nce)-506.8(th)-8.4(at)-508.2(may)-507(l)-6.6(ead)-506.8(to)-510.9(epi)-9.5(lep)-7.5(tic)-507.9(se)-7.7(izu)-9.5(re)-7.7(s)-501.3(\()]TJ 0 0 0 0.7 k 24.6106 0 TD (7)Tj 0 0 0 1 k 0.4834 0 TD (\),)Tj -25.094 -1.2114 TD [(which)-300.3(was)-300.4(supported)-306.5(by)-301.2(neuroimaging)-305.2(studies)-303.5(\()]TJ 0 0 0 0.7 k 19.3531 0 TD (10)Tj 0 0 0 1 k 0.9548 0 TD (\).)Tj -19.0428 -1.2114 TD 0.0689 Tc [(The)-571.4(c)-4.4(on)-4.8(tact)-5.1(in)-4.8(-associ)-5.3(a)-1.4(ted)-574.8(p)-1.9(rote)-4.4(in)-4.8(-2)-568.1(\()-5.8(C)2.8(ASPR2\))-572.8(is)-575.6(a)]TJ -1.2651 -1.2114 TD 0 Tc [(transmembrane)-336(protein)-337.4(which)-336.1(is)-330.8(located)-339.8(adjacent)-333.2(to)-331.9(VGKC)-334.4(on)]TJ 0 -1.2055 TD [(the)-207.1(cell)-213.6(membrane.)-210.4(The)-211.4(CASPR2-antibodies)-219.9(could)-210.9(be)-205.9(detected)-212.9(by)]TJ 0 -1.2114 TD [(immunoprecipitation)-492.1(on)-480.8(account)-484.4(of)-480.1(CASPR2)-484.6(which)-485.3(is)-480(a)-482(site)]TJ T* [(where)-430.6(most)-432.9(VGKC-antibodies)-439.7(bind)-434.8(to)-433.3(\()]TJ 0 0 0 0.7 k 16.6975 0 TD (13)Tj 0 0 0 1 k 0.9608 0 TD (,)Tj 0 0 0 0.7 k 0.6505 0 TD (17)Tj 0 0 0 1 k 0.9548 0 TD [(\),)-435.6(and)-435.5(CASPR2)]TJ -19.2636 -1.2114 TD [(plays)-322.3(a)-320.9(role)-326(in)-320.9(both)-321.3(the)-320.5(peripheral)-326.2(and)-328.1(central)-323.5(nervous)-322.1(systems)]TJ T* (\()Tj 0 0 0 0.7 k 0.3461 0 TD (18)Tj 0 0 0 1 k 0.9548 0 TD [(\).)-340.1(Therefore,)-345.8(we)-339.2(see)-337.7(patients)-343.1(with)-342.6(anti-CASPR2)-339.1(encephalitis)]TJ -1.3009 -1.2114 TD [(presenting)-478.8(limbic)-479.9(encephalitis)-484.9(\(fever,)-477.8(epilepsy,)-480.9(amnesia,)-483.5(sleep)]TJ 0 -1.2055 TD [(disorder,)-293.3(hallucination,)-295.8(psychosis,)-289.8(behavioral)-292.9(disorder\),)-296.5(Morvan)]TJ 0 -1.2114 TD [(syndrome)-447.1(\(sleep)-448.1(disorder,)-442.5(hallucination,)-451(psychosis,)-450.9(behavioral)]TJ T* [(disorder,)-376.9(constipation,)-383(tachycardia,)-378(hyperhidrosis,)-381.2(paresthetica,)]TJ T* [(weight)-208.6(loss\),)-204.8(and)-208.8(peripheral)-212.8(nerve)-210(hyperexcitability)-209(\(paresthetica,)]TJ T* 0.0269 Tc [(fasc)-4.7(iculation,)-530.9(li)-5.5(mb)-529.4(tw)-6.2(itch\),)-530.9(whic)-4.7(h)-528.2(i)0.5(s)-528.1(r)-3(are)-4.7(l)2.4(y)-529.6(s)-3(ee)-4.7(n)-530.1(i)0.5(n)-530.2(o)1.7(t)-5.3(h)2.9(e)-4.7(r)]TJ T* 0 Tc [(encephalitis.)-410.1(Moreover,)-408.5(the)-404(study)-408.1(of)-402.5(gene)-406.9(coding)-408.2(for)-408.5(CASPR2)]TJ T* [(has)-350.9(identi)]TJ /F10 1 Tf 3.9864 0 TD ()Tj /F9 1 Tf 0.5311 0 TD [(ed)-347(its)-351.1(role)-349.8(in)-350.8(neurodevelopmental)-360.8(disorders)-356.2(such)-353.2(as)]TJ -4.5175 -1.2055 TD [(autism,)-303.6(intellectual)-306.7(disability,)-300.6(and)-304.2(epilepsy)-305(\()]TJ 0 0 0 0.7 k 17.6643 0 TD (15)Tj 0 0 0 1 k 0.9608 0 TD (,)Tj 0 0 0 0.7 k 0.5192 0 TD (19)Tj 0 0 0 1 k 0.9548 0 TD (,)Tj 0 0 0 0.7 k 0.5192 0 TD (20)Tj 0 0 0 1 k 0.9608 0 TD (\).)Tj -20.3139 -1.2114 TD -0.0236 Tc [(I)5(n)-282.3(co)5(nc)4.5(lusion)4.2(,)-283(t)-2.1(h)6.1(e)-281.9(gre)4.5(a)1.6(t)-282.6(v)-1.2(ariabi)]TJ 11.7742 0 TD -0.0243 Tc [(lity)-276.4(of)-282.3(syndromes)-280.9(a)0.9(ssociated)-280.1(with)]TJ -13.0393 -1.2114 TD -0.0245 Tc [(anti-CASPR2)-207.9(a)0.7(ntibodies,)-206.3(despite)-205.3(i)2.8(ts)]TJ 13.4332 0 TD -0.0243 Tc [(rarity,)-206.1(s)-0.5(houl)4.9(d)-208.5(b)4.3(e)-211(n)3.5(oted)-202.5(in)-205.4(clinical)]TJ -13.4332 -1.2114 TD -0.0257 Tc [(pract)-4.2(i)1.6(c)-3.6(e)-481(as)-485.2(a)-483.8(d)-1(i)-4.4(f)62.4(fere)-3.6(nti)-4.4(a)-0.5(l)-485.9(d)-1(iagnosis)-485.2(of)-486.6(c)-3.6(o)2.9(n)-3.9(d)-1(iti)-4.4(o)2.9(n)-3.9(s)-1.9(,)-482(s)-1.9(uc)-3.6(h)-479.4(a)-0.5(s)-485.2(l)-2.5(imbic)]TJ T* -0.0243 Tc [(encephalitis)-376.4(and)-375.6(e)-2.2(pileps)5.5(y,)-379.2(especi)]TJ 12.4187 0 TD -0.0252 Tc [(ally)-378.8(in)-379.4(older)-383.3(p)-0.5(atients,)-380.1(newly)-378.8(o)3.4(nset)]TJ -12.4187 -1.2114 TD -0.0249 Tc [(psychiatr)4.9(i)-3.6(c)-390.7(s)-1.1(ymptom)5.3(s;)-397.7(neuropathi)]TJ 13.1109 0 TD -0.0246 Tc [(c)-390.4(p)0.1(ain;)-391.4(and)-393.8(i)2.7(diopathic)-390.4(a)0.6(taxia,)-391.4(as)]TJ 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[(reten)-5.5(t)6.1(ion)-530.6(o)1.2(f)-524(h)2.4(esit)6.1(ation,)-525.4(three)-524.4(h)2.4(ad)-521.8(hyperhidrosis,)-525.4(and)-527.8(o)1.2(ne)]TJ 27.4512 25.3685 TD 0 Tc [(presented)-372.1(with)-372.4(tachycardia.)-372(Moreover,)-378.6(weight)-369.7(loss)-366(was)-372(seen)-375.6(in)]TJ 0 -1.2114 TD [(two)-299.4(patients,)-304.2(and)-304.2(insomnia)-301.3(was)-300.4(seen)-303.9(in)-303(four.)]TJ 1.2651 -1.2114 TD [(Eight)-309.9(patients)-313.3(\(8/25\))-318(met)-314(the)-308.6(criteria)-320(for)-307.1(limbic)-318.7(encephalitis,)]TJ -1.2651 -1.2114 TD [(presenting)-413.1(with)-408.2(cognitive)-411.2(disturbance)-408.7(and)-411.7(mental)-410.8(or)-407.1(behavior)]TJ T* [(disorders.)-376.9(Short-term)-367.1(memory)-373.8(impairment)-372.4(was)-372(most)-373.3(common)]TJ T* [(\(4/8\),)-274.7(with)-270.9(MMSE)-279.3(scores)-273.4(of)-271.2(25,)-274.2(5,)-275.7(26,)-274.1(and)-274.4(26.)-268.2(Some)-274.6(experienced)]TJ 0 -1.2055 TD [(meaningless)-261.3(speech)-255.2(or)-257.9(mis-actions)-259.6(such)-257.7(as)-255.3(washing)-258.9(hands)-256.6(in)-261.2(the)]TJ 0 -1.2114 TD [(toilet)-333.2(or)-335.5(wearing)-332.1(the)-338.4(wrong)-330.5(clothes.)-338.9(Epileptic)-337.2(seizures)-335.3(occurred)]TJ T* 0.055 Tc [(in)-555.8(six)-551.2(o)0(f)-555.1(t)-1.1(he)-555.4(eight)-556(p)2.1(atients.)-556.5(F)-3.9(o)0(ur)-553.7(p)-3.9(a)2.7(tients)-553.7(\(4/25\))-556.8(had)]TJ T* 0.0256 Tc [(Morvan)-525.5(syndrome,)-526.2(w)-1.6(hich)-523.5(is)-523.5(characterized)-528.6(by)-524.9(involuntary)]TJ T* 0.0239 Tc [(muscle)-526.9(cramping)-526.6(and)-524.3(s)0(tif)64.3(f)-1.4(ne)]TJ 12.6395 0 TD 0.0231 Tc [(ss)-526(accomp)-5.9(anied)-525.1(b)-2.1(y)-521.5(i)-3.3(nsom)-6.3(nia,)]TJ -12.6395 -1.2114 TD 0.04 Tc [(halluc)-3.5(i)-4.3(n)2.1(at)-4.1(io)-3.1(ns,)-541.7(a)-6.4(nd)-544(aut)-4.1(o)2.9(n)-3.8(o)2.9(mi)-4.4(c)-540.6(s)-1.8(y)-3.3(m)-1.4(pto)-3.1(m)-1.4(s.)-541.7(Tw)-5.1(o)-540.1(o)-3.1(f)-540.3(t)1.8(he)-3.5(m)]TJ 0 -1.2055 TD 0 Tc [(e)-7.7(x)0(p)-8.6(e)-7.7(ri)-14.5(en)-9.8(c)-7.7(e)-7.7(d)-512.4(we)-11(ig)-10.1(ht)-515.7(l)-6.6(o)-7.3(ss)-519.2(of)-515.9(12)-516(an)-12.6(d)-512.4(1)0(5)-516(k)0(g)-13.8(.)-510.1(T)-6.6(u)0(m)-10.7(o)-7.3(r)-513.2(s)0(c)-13.7(r)0(e)-7.7(e)-7.7(n)-8(in)-10.6(g)]TJ 0 -1.2114 TD [(showed)-381.6(slightly)-379.4(elevated)-383.5(tumor)-378.4(markers.)-385.2(Three)-380.3(patients)-384.9(\(3/25\))]TJ T* [(ha)-16.7(d)-512.4(c)-7.7(e)-7.7(r)0(e)-13.7(b)-7.3(e)-7.7(l)-6.6(l)-6.6(u)-11.1(m)-512.8(s)0(y)-13.5(m)0(p)-16.7(t)-8.3(om)-12.8(s,)-522(an)-12.6(d)-518.4(t)0(h)-8.4(e)-7.7(i)-8.5(r)-513.2(c)-7.7(h)-12.1(ie)-10.3(f)-514.6(c)-7.7(o)-7.3(m)-11.5(pl)-11.8(ai)-13.2(n)-8(t)-8.3(s)-513.2(w)-9.3(e)-7.7(r)0(e)]TJ T* 0.0187 Tc [(wal)6.1(k)0.4(ing)-513.9(i)-1.8(nst)4.4(a)-3.8(b)5.5(i)-1.8(li)4.2(ty.)-515.2(R)0.1(elapse)-520.1(was)-518.4(r)0.8(ecorded)-517.6(i)4.2(n)-520.5(f)5.4(o)-0.5(ur)-518.4(pat)4.4(i)-1.8(en)4.7(ts,)]TJ T* 0.0249 Tc [(amon)4.9(g)-525.6(w)3.7(hi)4.4(ch)-524.2(t)4.6(h)0.9(ree)-519.9(e)-0.7(xperi)4.4(e)-0.7(nce)5.3(d)-523.3(bo)5.7(th)-518.3(slee)5.3(p)-523.3(d)1.8(isor)7(de)5.3(rs)-524.2(and)]TJ T* 0 Tc [(epileptic)-304.2(seizures.)]TJ /F1 1 Tf 11.9999 0 0 11.9999 306.1417 494.7022 Tm [(Laboratory)-304.2(Tests)]TJ /F9 1 Tf 9.5 0 0 9.5 306.1417 483.1936 Tm -0.021 Tc [(The)-470.3(r)-3.1(esults)-474.6(of)-476(laboratory)-470.1(t)0.5(e)-4.8(s)2.8(ts)]TJ 12.5977 0 TD -0.0206 Tc [(and)-473.3(i)0.7(maging)-475.7(a)4.6(r)-2.7(e)-475.9(s)3.2(um)3.7(mar)3.2(i)-5.3(zed)-473.3(in)]TJ /F13 1 Tf 0 0 0 rg -12.5977 -1.2114 TD -0.0215 Tc [(Table)-203.2(2)]TJ /F9 1 Tf 0 0 0 1 k 2.8943 0 TD -0.022 Tc [(.)-203.8(B)0(l)-4.7(ood)-206.2(an)-6.1(d)-200.2(C)-4.5(SF)-200.2(were)-202.8(obtaine)-5.8(d)-200.2(b)0.6(e)-5.8(f)0.5(ore)-202.8(t)-0.5(re)-5.8(at)-6.4(men)-6.2(t)-0.5(.)-203.8(A)2.6(l)-4.7(l)-201.7(patie)-5.8(n)-0.2(ts)]TJ -2.8943 -1.2055 TD -0.0199 Tc [(were)-403.6(positive)-403.6(for)-407.8(a)5.3(nti-C)3.5(A)-1.3(SPR)3.3(2)-406.2(antibody)-403.3(in)-409.8(C)3.5(S)0.5(F)-407(o)-3.3(r)-407.8(b)2.7(l)3.3(o)-3.3(od.)-404.6(I)2.8(n)-409.9(1)-0.4(9)]TJ 0 -1.2114 TD -0.0215 Tc [(pat)-5.9(i)-0.2(ents,)-376.4(t)0(he)-375.3(anti)-6.2(body)-375.1(w)-0.9(as)-373.6(detec)-5.3(t)0(ed)-378.7(only)-375.1(i)-6.2(n)-375.6(bloo)-4.9(d)-372.8(s)-3.6(ample)-5.3(s)-373.6(\(1:10)]TJ /F11 1 Tf 25.1477 0 TD 0 Tc (?Tj /F9 1 Tf -25.1477 -1.2114 TD -0.0215 Tc [(1:300\),)-292.9(w)5(hile)-291.8(six)-287.5(p)-2.8(at)-6(ients)-290.1(p)-2.8(re)-5.3(se)-5.3(nted)-289.2(a)-288.7(p)-2.8(ositive)-291.8(C)1.9(ASPR2)-288.5(a)-2.2(ntibody)-285.6(i)-0.2(n)]TJ T* -0.0218 Tc [(bot)-6.2(h)-338.2(b)0.8(lo)-5.2(od)-343.2(an)-6(d)-337.3(C)-4.3(SF)-337.3(\(1:32\).)-340.9(B)0.2(y)-339.6(a)-2.5(nalyz)-5.6(i)-0.5(ng)-339.6(white)-339.8(b)0.8(l)-4.5(ood)-343.2(cel)-4.5(l)-338.7(\()-1.1(WBC\))]TJ T* -0.022 Tc [(count)-6.5(s)-493.5(an)-6.2(d)-492.6(p)-3.3(ro)-5.4(tein)-495.5(le)-5.8(vels,)-496.3(w)-1.4(e)-495.2(f)0.5(ound)-498.6(eviden)-6.2(ce)-495.2(of)-494.9(in)]TJ /F10 1 Tf 20.9942 0 TD 0 Tc ()Tj /F9 1 Tf 0.5132 0 TD -0.0211 Tc (ammation.)Tj -21.5074 -1.2114 TD -0.0215 Tc [(WBC)-224.8(c)0.6(ounts)-224.4(i)-0.2(n)-220.5(t)-5.9(he)-226.1(CSF)-223.6(w)-0.9(ere)-220.2(e)0.6(levate)-5.3(d,)-227.2(rang)-5.1(ing)-219.9(f)-5(rom)-224(1)-2(1)-222.8(t)0(o)-225.7(4)4(32)-222.8(ce)-5.3(lls/)]TJ 0 -1.2055 TD -0.0209 Tc [(ul)-248.3(in)-243.8(e)-4.7(i)0.4(ght)-244.1(p)-2.2(atients)-253.7(\()-0.2(8/25\).)-244.5(M)-1.2(eanwhile)-4.7(,)-244.5(p)-2.2(ro)-4.3(teins)-253.7(i)0.4(n)-243.8(C)-3.4(SF)-246.9(decreased)-246.9(i)0.4(n)]TJ 0 -1.2114 TD -0.0202 Tc [(seven)-266.9(o)2.4(f)-260.3(2)-0.7(5)-263.3(\()0.5(ranging)-260.4(f)-3.7(rom)-258.5(23.2)-263.3(t)1.3(o)-260.2(130)5.3(.5)-263.3(mg/d)4.5(l\))-262(and)-264.1(i)1.1(ncreased)-264.1(in)-261(10)]TJ T* -0.0209 Tc [(\(ra)4.3(n)-5(ging)-320.8(from)-318.9(480)-317.7(to)-314.6(1,337.6)-317.7(m)3.4(g/dl\).)-322.1(In)-321.3(eight)-315.7(p)-2.2(atients,)-322.1(proteins)-319.3(in)]TJ T* 0 Tc [(CS)14(F)-500.5(w)0(e)12.9(r)11.9(e)-503(a)0(t)-496.3(n)0(o)14.6(r)0(m)18.3(a)0(l)-494.6(l)0(e)15.5(v)0(e)14.7(l)-501.9(\(r)14.7(an)17.2(gi)13.8(ng)-492.9(fr)16.5(om)-496.2(15)15.1(0)-499.7(t)0(o)-499(4)0(5)21.1(0)-505.7(mg)16.8(/d)12.5(l\))20.1(.)]TJ T* -0.0215 Tc [(Sev)-5.1(e)0.6(ntee)-5.3(n)-441.3(p)-2.8(ati)-6.2(e)0.6(nts)-445.2(r)2.3(e)-5.3(ceiv)-5.1(e)0.6(d)-438.4(i)-6.2(mmun)]TJ 14.0359 0 TD -0.0206 Tc [(ological)-439(evaluations,)-441.1(although)]TJ -14.0359 -1.2114 TD -0.022 Tc [(not)-269(a)-2.7(ll)-267.3(of)-268.1(them)]TJ /F10 1 Tf 5.9438 0 TD 0 Tc ()Tj /F9 1 Tf 0.5132 0 TD -0.0211 Tc [(nished)-270.9(all)-266.4(t)0.4(est)-262.2(i)-5.8(tems.)-268.6(N)1.8(ormal)-266.4(t)0.4(hyroid)-265(f)-4.6(u)3.6(n)-5.3(c)1(tion)-267.8(was)]TJ -6.457 -1.2114 TD -0.0218 Tc [(fo)-5.2(un)-6(d)-265.7(i)-6.5(n)-268.5(m)-3.5(ost)-274.8(p)2.9(atie)-5.6(nts,)-269.3(exce)-5.6(pt)-274.8(one)-274.2(p)2.9(atie)-5.6(nt)-268.8(whose)-274.2(F)-3.1(T4)-270.9(was)-266.5(e)-5.6(lev)-5.4(a)3.4(te)-5.6(d)]TJ 0 -1.2055 TD -0.0208 Tc [(\(17.1)-204.2(p)3.9(mol/L\).)-202.6(P)-1.9(ositive)-207.5(t)0.7(hyroid)-205(peroxidase)-201.6(antibodi)-5.5(es)-205.8(\(TPO)-206.8(Ab\))-208.9(a)4.4(n)-5(d)]TJ 0 -1.2114 TD -0.0212 Tc [(thyro)-4.6(g)1.2(lob)-4.6(u)3.5(lin)-470.8(a)-1.9(ntibo)-4.6(d)3.5(ie)-5(s)-468.8(\()-0.5(TG)-465(Ab\))-471.9(w)-0.6(ere)-470.5(d)-2.5(etect)-5.7(ed)-468(in)-470.8(thre)-5(e)-470.5(o)1.4(f)-470.2(1)-1.7(5)]TJ T* [(pat)-5.5(i)0.2(ents.)-250.7(O)-4.2(ne)-255.6(patie)-4.9(n)0.7(t)-250.2(w)-0.5(as)-253.9(positive)]TJ 13.0393 0 TD -0.0197 Tc [(for)-252.5(R)3.5(O-)6.1(52)-250.8(antibody,)-255.2(a)5.5(nd)-251.6(another)]TJ -13.0393 -1.2114 TD -0.0216 Tc [(was)-266.3(p)-2.9(ositive)-268(f)-5.1(or)-272.3(an)-5.8(ti-streptolysin)-274.3(O)1.3(.)-269.1(N)1.3(i)-6.3(n)0.2(etee)-5.4(n)-268.3(p)-2.9(ati)-6.3(e)0.5(nts)-272.3(u)3.1(n)-5.7(d)3.1(e)-5.4(r)2.2(wen)-5.7(t)-268.6(a)]TJ T* -0.0214 Tc [(tumo)-4.8(r)-242.2(s)-3.5(creen)-5.6(ing)-249.7(t)0.1(est,)-245(non)-5.6(e)-243.9(o)-4.8(f)-243.6(whom)]TJ 14.0658 0 TD [(was)-248.3(p)-2.8(re)-5.3(viously)-249.8(d)3.2(iag)-5.1(n)0.3(osed)-247.5(with)]TJ -14.0658 -1.2114 TD -0.0209 Tc [(a)-449.2(t)0.6(umor.)-447.4(A)-449.8(slight)-452.9(ele)-4.7(v)1.5(ation)-452.6(\()-0.2(with)]TJ 13.3735 0 TD -0.0214 Tc [(in)-453.1(triple)-452.8(of)-452.5(in)-5.6(crease\))-454.2(o)1.2(f)-452.5(t)0.1(umor)]TJ -13.3735 -1.2055 TD -0.0206 Tc [(ma)4.6(rkers,)-500.8(including)-505.5(Carbohydra)]TJ 12.4485 0 TD -0.02 Tc [(te)-505.1(a)5.2(n)-4.2(tigen199)-495.8(\(CA-)5.8(199\),)-500.2(H)0(uman)]TJ -12.4485 -1.2114 TD 0 Tc 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0.0227 Tc [(pa)-5.8(ti)-3.7(e)-2.9(n)-3.2(ts)-526.4(fai)-3.7(l)-1.8(e)-2.9(d)-525.5(to)-527.6(re)-2.9(spon)-3.2(d)-525.5(t)-3.5(o)-521.6(t)-3.5(he)-2.9(rapy)-2.7(,)-529.1(i)2.2(n)-3.2(c)-2.9(lud)-6.3(i)2.2(n)-3.2(g)-527.8(on)-3.2(e)-528.1(w)1.5(ho)]TJ T* 0 Tc [(re)-7.7(ma)-10.2(ine)-12.3(d)-506.4(s)0(e)-7.7(v)0(e)-9.2(r)0(e)-7.7(l)0(y)-509.4(d)0(i)-7.7(s)0(a)-10.6(ble)-9.6(d)-506.4(\()0(m)-8.7(R)0(S)-511.4(=)-508.1(4\))-7.5(.)-504.1(N)-7(o)-508.5(pat)-12.1(ien)-12.3(t)-503.6(r)0(e)-7.7(por)-12.4(te)-10.1(d)]TJ T* 0.0389 Tc [(di)6.5(sa)4.5(bility)-535.5(pr)3.1(ogres)3.1(s)3.1(i)0.5(on.)-536.8(T)2.4(hr)3.1(ee)-535.7(pa)4.5(tients)-534(und)3.9(e)-4.6(r)3.1(w)-0.2(ent)-536.3(l)2.4(u)3.9(m)-2.5(ber)]TJ 27.4512 67.1421 TD 0 Tc [(puncture)-345.6(again)-343.6(after)-338.4(treatment,)-347.9(showing)-339.1(decreased)-350.2(protein)-343.4(and)]TJ 0 -1.2114 TD [(WBC)-430.7(in)-434.3(CSF)-432.8(after)-433.8(treatment.)-431.4(Relapse)-438.3(occurred)-434.6(in)-428.3(four)-437.6(of)-426.4(25)]TJ T* [(patients)-343.1(\(4/25\))-341.9(after)-344.3(2)-344.5(months.)-342.5(Insomnia)-341.6(and)-340(epileptic)-345.9(seizures)]TJ T* [(both)-297.5(appeared)-308.7(in)-303(three)-298.4(of)-301.1(them)-302.2(\()]TJ /F13 1 Tf 0 0 0 rg 13.3019 0 TD [(Table)-298.8(3)]TJ /F9 1 Tf 0 0 0 1 k 3.1211 0 TD (\).)Tj /F1 1 Tf 11.9999 0 0 11.9999 306.1417 633.0329 Tm (DISCUSSION)Tj /F9 1 Tf 9.5 0 0 9.5 306.1417 613.077 Tm [(We)-489.8(re)16.1(tr)15.5(os)16.6(pe)17(ct)13.8(iv)19.8(el)15.5(y)-496.8(a)0(n)11.2(a)0(l)18.6(y)0(z)14.7(e)0(d)-490.3(2)0(5)-486.2(p)0(a)14.1(t)0(i)18.9(e)0(n)14.1(t)0(s)-491.7(w)0(i)18(t)0(h)-491.8(c)0(o)20.8(n)]TJ /F10 1 Tf 20.6899 0 TD ()Tj /F9 1 Tf 0.5192 0 TD [(rm)12.3(ed)-490.3(an)17.2(ti)18.9(-)]TJ -21.209 -1.2114 TD [(C)17.5(A)12.7(S)14.5(P)13(R2)-381(a)13.3(n)15.9(t)15.6(i)15.3(bo)27.3(d)12.7(y)16.4(-)13.8(a)13.3(s)17.9(s)11.9(o)16.6(c)0(i)25.5(a)13.3(t)15.5(e)16.2(d)-399(e)16.2(n)15.8(c)0(e)26.4(p)12.7(h)17.8(a)13.3(li)26.6(t)15.5(i)15.3(s)-393.9(i)15.3(n)]TJ /F10 1 Tf 17.9447 0 TD ()Tj /F9 1 Tf 0.5192 0 TD [(v)16.4(e)-395.6(c)16.2(e)0(n)26(t)15.5(er)28.1(s)11.9(.)-396.7(I)16.7(n)-395.9(o)16.6(u)12.7(r)]TJ -18.4639 -1.2114 TD -0.0145 Tc [(stud)4.2(y)-14.5(,)-347(mal)2.8(e)-362.4(patien)-14.5(t)10.9(s)-360.7(acc)-14.5(o)12.3(unted)-365.8(f)2(or)-366.6(a)-359.3(l)2.8(arger)-366.6(p)4.2(roportio)-14.5(n)12(,)-363.4(and)-359.8(t)1(hey)]TJ T* 0 Tc [(w)14.6(e)16.2(r)11.9(e)-252.4(o)16.6(l)0(d)30(e)0(r)-240.5(t)15.6(h)11.8(a)13.3(n)-246.7(f)0(e)26.7(m)12.3(a)13.3(l)17.3(es)-240.5(w)14.6(h)17.8(en)-242.5(i)15.3(n)15.8(i)15.3(t)15.5(ia)28.6(l)-251.3(s)11.9(y)16.4(m)12.3(p)12.8(t)15.6(o)16.6(m)12.3(s)-250.7(a)13.3(p)12.8(p)12.7(e)16.2(a)13.3(r)17.9(e)0(d)-239.6(\()14.8(m)12.3(e)16.2(d)12.7(i)15.3(a)13.3(n)]TJ T* -0.0134 Tc [(at)-230.6(44)]TJ /F14 1 Tf 2.1066 0 TD -0.0193 Tc (vs)Tj /F9 1 Tf 0.9727 0 TD -0.014 Tc [(38)-233.2(years)-228.9(o)-14(l)13.9(d)-1.2(\).)-231.6(T)-14(h)15(i)-14(s)-219.5(resul)3.3(t)-231.2(is)-234.8(simil)3.3(a)-0.7(r)-234.8(t)1.5(o)-230.1(t)1.6(hose)-230.6(o)-14(f)-219.6(other)-234.8(s)-2.1(tud)4.7(i)-14(e)11.5(s)]TJ -3.0793 -1.2114 TD -0.0153 Tc [(in)-285.9(Asia)-288.5(\()]TJ 0 0 0 0.7 k 3.3598 0 TD -0.0135 Tc (21)Tj 0 0 0 1 k 0.925 0 TD 0 Tc [(\).)-256.6(A)12.6(s)-268.6(k)17.6(n)0(o)26.5(w)14.6(n)15.8(,)-271.3(a)13.3(u)12.8(t)15.5(o)16.6(i)15.3(m)12.3(m)12.3(u)18.7(ne)-254.4(en)26(c)16.2(e)0(p)22.9(h)17.8(a)13.3(l)17.3(it)24.9(i)15.3(s)-268.6(i)15.3(s)-268.6(ch)28(a)13.3(r)11.9(a)19.3(c)0(t)25.7(e)16.2(r)11.9(i)15.3(z)16.2(e)0(d)]TJ -4.2848 -1.2055 TD [(b)16.6(y)-210.4(a)13.3(c)16.2(u)12.7(t)15.6(e)-210.6(o)16.6(r)-208.9(s)11.9(u)12.7(b)16.6(a)13.3(c)16.2(u)12.8(t)15.5(e)-210.6(o)16.6(ns)27.8(et)25.7(.)-205.7(O)0(u)23.7(r)-208.9(p)12.7(a)19.3(ti)24.9(e)16.2(n)15.8(ts)-199.3(h)17.8(a)13.3(d)-208(a)-213.5(m)18.3(e)0(d)28.9(i)0(a)28.6(n)-210.9(co)26.8(u)12.7(r)17.9(s)11.9(e)-210.6(o)16.6(f)-210.3(1)13.5(7)]TJ 0 -1.2114 TD [(d)12.7(a)13.3(y)16.4(s)-191(b)16.6(e)16.2(fo)27.1(r)11.9(e)-186.7(a)13.3(d)12.7(m)18.3(i)15.3(s)11.9(s)11.9(i)15.3(o)16.6(n)15.8(,)-193.8(w)14.6(h)17.8(i)15.3(ch)-174.9(m)12.3(i)15.3(g)16.4(h)11.8(t)-187.4(i)15.3(m)12.3(p)12.7(l)17.3(y)-186.5(th)27.4(a)13.3(t)-187.3(CA)30.1(S)14.5(P)13(R2)24.8(-)19.8(a)13.3(s)11.9(s)11.9(o)16.6(c)16.2(i)15.3(a)13.3(t)15.5(ed)]TJ T* -0.0145 Tc [(en)-14.5(c)11.5(e)1.7(pha)4.8(l)-14.5(i)12.1(t)1(is)-289(h)3.3(a)-1.2(s)-289(a)-287.7(r)3.4(e)-14.5(l)13(a)-1.2(tive)-14.5(l)13(y)-284.6(short)-285.4(c)1.7(ours)3.4(e)-290.7(o)2.1(f)-284.5(p)-1.8(rogression.)-285.9(H)-0.5(o)-14.5(w)10.7(eve)-14.5(r)13.6(,)]TJ T* 0 Tc [(w)14.6(e)-461.2(d)12.7(i)15.3(d)-458.7(n)0(o)26.5(t)15.6(i)15.3(c)0(e)-451(t)15.5(h)17.8(a)13.3(t)-461.9(p)12.8(a)13.3(t)15.6(i)15.3(e)16.2(n)15.9(t)0(s)-450(e)16.2(nr)27.7(o)16.6(l)0(l)28.6(e)0(d)-448.5(i)15.3(n)-461.6(o)0(u)29.4(r)-465.5(s)17.9(t)15.6(u)12.7(d)12.7(y)-461(w)14.6(e)16.2(nt)-446(to)-445.2(th)27.4(e)]TJ T* -0.0152 Tc [(ho)-15.2(s)13.3(p)-2.4(it)-15.2(a)13.6(l)-302.3(soon)-15.2(e)10.8(r)-301.7(than)-303.7(those)-297.4(i)0.1(n)-303.7(o)1.4(ther)-301.7(reports)-301.7(\()]TJ 0 0 0 0.7 k 17.4136 0 TD -0.0135 Tc (21)Tj 0 0 0 1 k 0.931 0 TD 0 Tc (,)Tj 0 0 0 0.7 k 0.5013 0 TD -0.0135 Tc (22)Tj 0 0 0 1 k 0.931 0 TD -0.0148 Tc (\).)Tj -18.5117 -1.2114 TD 0.0092 Tc [(The)-511.7(i)0.7(ni)-5.3(tial)-510.6(manif)-4.2(e)1.5(stati)-5.3(o)2(n)-512(a)-1.4(t)-506.4(o)-4(nset)-512.3(v)-4.2(a)9.2(r)-7.4(i)0.7(e)-4.5(s)-510(by)-511.5(pati)-5.3(ent)-5.1(.)-506.8(Fo)-4(r)]TJ -1.2651 -1.2055 TD 0.0205 Tc [(instanc)-5.1(e)0.9(,)-525.4(o)1.3(ne)-524.3(pat)-5.7(i)0(ent)]TJ /F10 1 Tf 9.7034 0 TD 0 Tc ()Tj /F9 1 Tf 0.555 0 TD 0.0225 Tc [(r)4.6(s)-1.4(t)-516.9(s)-1.4(uf)62.9(fered)-519.7(f)-2.8(rom)-520.2(r)4.6(ight)-516.9(upp)5.4(er)-520.6(limb)]TJ -10.2584 -1.2114 TD 0 Tc [(numbness,)-444.4(and)-441.5(another)-435.9(presented)-443.7(blurred)-443.7(vision)-439.7(as)-440.3(an)-436.3(initial)]TJ T* [(symptom,)-292.8(which)-288.4(may)-292.2(be)-289.5(identi)]TJ /F10 1 Tf 12.4843 0 TD ()Tj /F9 1 Tf 0.5311 0 TD [(ed)-293.3(as)-291.1(cerebrovascular)-294.7(disease)-290.4(at)]TJ -13.0155 -1.2114 TD [(the)-296.6(beginning.)-300.7(This)-295.8(could)-294.5(hinder)-298.1(timely)-300.8(and)-292.3(accurate)-302.4(diagnosis.)]TJ T* [(An)-293.8(animal-model)-301.1(study)-300.6(demonstrated)-300.6(that)-295.9(CASPR2)-299.6(was)-294.4(widely)]TJ T* [(and)-483.3(deeply)-481.4(expressed)-484.5(in)-482.1(the)-481.6(cortex)-482(and)-483.3(involved)-482(motor)-482(and)]TJ T* [(sensory)-323(pathways)-326.1(and)-322.1(the)-320.5(limbic)-324.7(circuit)-326.5(\()]TJ 0 0 0 0.7 k 16.799 0 TD (23)Tj 0 0 0 1 k 0.9608 0 TD [(\).)-322.2(This)-325.7(may)-322(explain)]TJ -17.7597 -1.2055 TD [(the)-302.6(diverse)-299.2(symptoms)-308(observed.)]TJ 1.2651 -1.2114 TD [(During)-326.7(the)-332.4(course,)-329.1(muscle)-331.2(cramps)-333.4(or)-329.5(myokymia)-327.3(was)-330.2(one)-327.3(of)]TJ -1.2651 -1.2114 TD [(mo)-12.8(st)-515.6(c)-7.7(o)0(m)-6.9(m)-11.5(on)-516.6(sy)-7.5(mp)-16.7(to)-9.6(ms)-518.8(an)-12.6(d)-506.4(w)-9.3(as)-517.9(re)-13.7(co)-9(g)-7.5(n)0(i)-10.6(z)-7.7(ed)-514.1(a)-10.6(s)-507.3(pe)-12.9(ri)-14.5(ph)-11.2(e)-7.7(r)0(a)-10.6(l)]TJ T* [(nerve)-442.7(hyperexcitability)-453.7(\(PNH\).)-442.6(An)]TJ /F14 1 Tf 14.7938 0 TD [(in)-440.3(vitro)]TJ /F9 1 Tf 3.5269 0 TD [(experiment)-450.1(found)]TJ -18.3207 -1.2114 TD [(that)-272(CASPR2)-275.7(tends)-273.9(to)-272.2(express)-274.7(in)-273.2(inhibitory)-273(neurons)-274.9(\()]TJ 0 0 0 0.7 k 21.4537 0 TD (24)Tj 0 0 0 1 k 0.9548 0 TD [(\),)-274.5(which)]TJ -22.4086 -1.2114 TD [(means)-246.7(anti-CASPR2)-255.6(antibodies)-250.4(can)-247.1(result)-248.7(in)-243.3(neuronal)-250.3(excitation)]TJ 0 -1.2055 TD [(through)-368.6(combination)-367.6(with)-366.4(its)-369(target.)-367.5(Among)-367.8(PHN)-361.9(syndromes,)]TJ 0 -1.2114 TD [(Morvan)-216.6(syndrome)-220.3(is)-217.4(notably)-216.6(special,)-222.2(not)-220.5(only)-214.4(because)-219.2(of)-217.5(its)-219.8(close)]TJ T* (speci)Tj /F10 1 Tf 1.9813 0 TD ()Tj /F9 1 Tf 0.5311 0 TD [(city)-342.4(to)-343.8(Anti-CASPR2)-345.8(antibody)-349.1(but)-343(also)-340.8(because)-350.5(both)-345.2(the)]TJ -2.5124 -1.2114 TD [(central)-407(and)-405.7(peripheral)-403.7(nervous)-411.6(systems)-405.1(are)-406.2(involved)-404.4(\()]TJ 0 0 0 0.7 k 22.3489 0 TD (15)Tj 0 0 0 1 k 0.9608 0 TD [(\).)-405.8(For)]TJ -23.3097 -1.2114 TD [(i)-8.5(n)0(s)-8.1(t)-8.3(an)-12.6(c)-7.7(e)-7.7(,)-510.1(me)-13.3(mo)-12.8(ry)-514.8(l)-6.6(o)-7.3(ss)-12(,)-516(s)0(l)-6.6(e)-7.7(e)-7.7(p)0(i)-13.7(n)-8(g)-508.8(d)0(i)-13.7(s)0(o)-13.2(r)0(d)-11.2(e)-7.7(r,)-516.1(a)-10.6(n)0(d)-514.5(p)-11.1(sy)-13.5(ch)-7.8(o)-7.2(s)0(i)-14.5(s)-513.2(ar)-10.6(e)]TJ T* 0.0381 Tc [(typically)-536.3(s)-3.7(een)-542.8(in)-536.9(Morvan)-542.8(sy)-5.2(ndrome)-536.5(and)-539.9(n)0.2(o)-542.1(o)1(ther)-540.8(PN)-4.7(H)]TJ T* 0 Tc [(sy)-13.5(n)-8(d)0(r)-11.2(o)-7.2(me)-13.3(s,)-522(su)-17.1(ch)-515.1(a)-10.6(s)-513.2(I)-7.2(s)0(a)-10.6(a)-10.6(c)-7.7(s)-513.2(s)0(y)-13.5(n)-8(dr)-11.2(o)-7.3(m)0(e)-520.5(o)-7.3(r)-513.2(c)-7.7(ra)-10.6(mp)-16.7(-f)-11.4(a)-10.6(s)0(c)-13.7(i)0(c)-10.3(u)-11.1(l)-6.6(a)0(t)-12.9(i)0(o)-9.8(n)]TJ 0 -1.2055 TD 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